Pondering vexing issues in infection prevention and control
Thursday, March 11, 2010
Herd Immunity in Influenza
Mark Loeb and colleagues have produced another fine study. They report in JAMA the results of a cluster-randomized trial where they vaccinated children aged 3-15 in 49 small communities in rural Canada. Children were vaccinated with either inactivated trivalent influenza vaccine or hepatitis A vaccine as a control. Confirmed influenza (RT-PCR) was 61% lower in non-recipients in the communities where children were vaccinated (3.1%) compared to non-recipients in unvaccinated communities (7.6%). Their main conclusion was that "a significant herd immunity effect can be achieved when the uptake of vaccine is approximately 80% in clusters in which children and adolescents aged 3 to 15 years are immunized." One note: this study was completed during the 2008-2009 season.
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