Potential new option for treating C. difficile

A small case series in Clinical Infectious Diseases describes four patients with severe refractory Clostridium difficile infection successfully treated with IV tigecycline. Three of the patients had failed standard therapy with metronidazole and vancomycin. This is potentially important given the rising incidence in C. difficile. Unfortunately, my experience with this antibiotic for other indications has been poor since most of my patients could not tolerate the severe nausea it causes.