One dose should do it...

There are a number of novel H1N1 articles, and an editorial, now available online from the New England Journal of Medicine. The one you will be hearing about on CNN is this one, which demonstrates that a single 15 microgram dose of the non-adjuvanted vaccine produces protective antibody titers in over 95% of healthy adults (aged 18-64). There are a few caveats about the trial that are covered in the accompanying editorial, including that it was conducted in Australia while the novel H1N1 was circulating. But overall, the study is reassuring—it will be a lot easier to roll out this vaccine if only one dose is needed for most adults. Whether this holds up in kids, the elderly, and the immunocompromised remains to be seen.