Deus ex machina (Part 4): Flavonoid-like Molecules
Fowler et al. in PLoS ONE examined flavonoids, which are abundant plant metabolites with anti-infective activity. They used a natural flavonoid scaffold to create novel flavanones and tested their efficacy versus E coli, B subtilis, Cryptococcus neoformans and Aspergillus fumigatus. They screened eight molecules and found that 4-chloro-flavanone was the most potent antimicrobial compound. What did Ralph Waldo Emerson say? I think it's that "We judge of man's wisdom by his hope." Keep hope alive.
Source: Fowler et al. PLoS ONE 2011
Via: Hampton T, JAMA 2011